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Rayyan brings reference handling, collaboration, deduplication, screening, extraction, risk-of-bias assessment, and reporting into a systematic-review workflow. Its ResearchPilot tools screen against custom criteria, explain suggested decisions, and extract answers from PDFs and metadata for researcher review. The API supports access to reviews, references, decisions, and metadata, while mobile apps support on-the-go or offline work. Rayyan accepts exported reference files rather than connecting directly to databases. Its free plan allows three active reviews and limited mobile access; paid plans start at $8.33 per seat per month, billed annually.

  1. 1

    ASReview

    Free plan Open source APILinuxMac+3

    Free AI-prioritized screening with team simulation — ASReview prioritizes records with active learning and supports model simulations, while Rayyan adds extraction, risk-of-bias assessment, and reporting.

    9.3 Free plan Visit site
  2. 2

    RobotReviewer

    Free plan Open source APILinuxMac+3

    Annotating clinical-trial PDFs for PICO and bias — RobotReviewer annotates trial PDFs for PICO and likely bias, while Rayyan covers a broader review workflow with collaboration and reporting.

    Free plan Visit site
  3. 3

    Universal SLR Assistant

    Free plan Open source APILinuxMac+3

    Local systematic or scoping review workspaces — Universal SLR Assistant offers local SQLite workspaces and extensive workspace exports, while Rayyan provides an API and mobile apps.

    8.5 Free plan Visit site
  4. 4

    Abstrackr

    Free plan Web

    Blinded citation screening with live PRISMA reporting — Abstrackr centers on citation screening, blinded team review, and PRISMA flow reporting, while Rayyan covers additional review stages.

    7.3 Free plan Visit site
  5. 5

    Axelium

    Free plan ExtensionWeb

    Reviews needing synthesis, statistics, and living updates — Axelium extends its workflow to GRADE, statistical synthesis, network meta-analysis, and living reviews beyond Rayyan’s review stages.

    Free plan · paid from $29/mo Visit site
  6. 6

    Elicit

    Free plan APIWeb

    Evidence discovery and cited research answers — Elicit’s Research Agent searches scientific sources and its paper corpus, while Rayyan focuses on managing systematic-review workflows.

    Free plan · paid from $11/user/mo Visit site
  7. 7

    LitFlow

    Free plan Self-hostedWeb

    Auditable literature reviews with source-linked AI suggestions — LitFlow adds database search, snowballing, qualitative coding, and methods reporting, while Rayyan offers API access and a mobile app.

    7.0 Free plan Visit site
  8. 8

    Bango

    Free plan LinuxMacWindows
    7.5 Free plan Visit site
  9. 9

    Buhos

    Free plan APILinuxMac+3
    7.3 Free plan Visit site
  10. 10

    CADIMA

    Free plan Web
    7.1 Free plan Visit site
  11. 11

    Catchii

    Free plan Web
    7.1 Free plan Visit site
  12. 12

    Colandr

    Free plan Web
    7.1 Free plan Visit site
  13. 13

    Covexe

    Free plan Web
    7.1 Free plan · paid from $99/yr Visit site
  14. 14

    ReviewAid

    Free plan LinuxMacSelf-hosted+2
    7.1 Free plan Visit site
  15. 15

    RevMan

    Free plan LinuxMacWeb+1
    7.1 Free plan · paid from £80/user/yr · 30-day trial Visit site
  16. 16

    EPPI-Reviewer

    Free plan Web
    7.0 From £10/user/mo Visit site
  17. 17

    HAWC

    Free plan Web
    6.9 Free plan Visit site
  18. 18

    Nested Knowledge

    Free plan Web
  19. 19

    Parsifal

    Free plan Web
    6.8 Free plan Visit site
  20. 20

    Sysrev

    Free plan APISelf-hostedWeb
    6.8 Free plan Visit site
  21. 21

    SWIFT-Review

    Free plan MacWindows
    6.7 Free plan Visit site
  22. 22

    Silvi

    Free plan Web
    6.6 Free plan · paid from €19/mo Visit site
  23. 23

    ReviQ

    Free plan Self-hostedWeb
    6.5 Free plan Visit site
  24. 24

    SyRF

    Free plan Web
    6.5 Free plan Visit site
  25. 25

    Systematicly

    Free plan Web
    6.5 Free plan · paid from $19 Visit site
  26. 26

    PICO Portal

    Free plan Web
    6.2 Free plan · 14-day trial Visit site
  27. 27

    LASER AI

    Free trial AndroidiPhoneWeb
    6.1 From $3,000 Visit site

A different tool may suit you if your priority is narrower screening, local control, clinical-trial PDF annotation, or a workflow with more statistical synthesis. Compare how each option handles human review of AI suggestions, team decisions, imports and exports, and the stages beyond screening. Also weigh platform and setup requirements: some alternatives are free but call for local services or a self-hosted environment, while others rely on external AI providers. Choose according to the review work you need, not just the screening step.

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