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When Should Adults Get the Shingles Vaccine, and How Many Doses Are Needed?

Most adults need two Shingrix doses: routinely from age 50, or from age 19 if immunocompromised. The usual interval is 2–6 months.
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In the United States, adults should get two doses of Shingrix: routinely starting at age 50, or starting at age 19 if they are or will be immunocompromised because of a disease or treatment. The usual gap is 2–6 months. Some immunocompromised adults may get the second dose after 1–2 months when earlier protection is useful.

Who should get the shingles vaccine, and when?

Adults age 50 and older

CDC recommends two doses of Shingrix, also called recombinant zoster vaccine (RZV), for adults age 50 and older who have healthy immune systems. The recommendation applies whether or not you have had shingles before or previously received Zostavax. Routine screening or laboratory testing for prior chickenpox (varicella) is not needed for this age group. CDC’s vaccine recommendations.

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Adults age 19 and older who are or will be immunocompromised

Two doses are also recommended for adults age 19 and older who are, or will be, immunodeficient or immunosuppressed because of a disease or therapy. This includes people preparing to begin immunosuppressive treatment. If treatment is planned, discuss vaccine timing with the clinician managing it; when possible, CDC advises vaccination before immunosuppression. CDC guidance for clinicians.

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How far apart should the two doses be?

Situation Timing
Adults age 50 and older Usually 2–6 months between doses.
Adults age 19 and older who are or will be immunocompromised Usually 2–6 months; 1–2 months may be used when earlier completion is beneficial, such as avoiding a period of more intense immunosuppression.

The shorter interval is an option for some immunocompromised adults, not a different number of doses. A clinician can help coordinate the timing around a condition or planned treatment. CDC timing guidance.

What if the second dose is late?

If more than six months have passed since the first dose, get the second dose as soon as possible. You do not need to restart the series. CDC’s instruction for delayed doses.

Does prior shingles or Zostavax change the recommendation?

No. A previous shingles episode does not remove the recommendation for Shingrix, and CDC specifies no fixed waiting period after shingles. Do not get vaccinated during an acute shingles episode; wait until the acute illness has ended and symptoms have abated. CDC shingles vaccine information.

Shingrix is still recommended for people who previously received Zostavax. Wait at least eight weeks after Zostavax before receiving Shingrix. Zostavax is no longer available in the United States. CDC recommendations.

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What protection does Shingrix provide?

CDC reports that Shingrix is more than 90% effective against shingles and postherpetic neuralgia in adults age 50 and older with healthy immune systems. That effectiveness figure is specific to this group and should not be assumed to apply equally to every immunocompromised person. CDC estimates that about 1 in 3 people in the United States will develop shingles during their lifetime. CDC shingles vaccine information.

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What reactions are common, and when might vaccination be postponed?

Common reactions include a sore arm, redness or swelling, tiredness, muscle pain, headache, shivering, fever, stomach pain, and nausea. They usually resolve on their own within 2–3 days. CDC advises getting the second dose even if you had these reactions after the first. CDC Recombinant Zoster Vaccine VIS.

Tell the vaccination provider if you have had a severe allergy or a severe reaction to a previous dose, currently have shingles, or are pregnant; the provider may decide to postpone vaccination. People who are moderately or severely ill should usually wait until they recover, while a minor illness such as a cold does not necessarily require postponement. Shingrix may be given at the same visit as other adult vaccines, at a different injection site. CDC vaccine information statement and CDC provider guidance.

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