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Repair Windows errors before they cause bigger problemsFix Now →Fix the driver behind crashes, sound loss and screen glitchesFind Drivers →A Synaptic Vessel permanently improves how much health each charge of Mether’s Pulse restores—but only after you spend it at a Beacon. It does not add healing charges; that is the job of a Revered Gland. Early leads include Merrick’s shop in southern Marrow Keep, a reward after defeating Grisha in the Flooded Village, and a camp south of Stonebled Gate Beacon.
What does a Synaptic Vessel do?
It upgrades the efficiency of Mether’s Pulse, increasing the health restored by each charge. The Mortal Shell II Database, an unofficial fan-made database, describes the item as something you “Consume at Beacons to improve your Mether’s Pulse efficiency.” A guide from Nerd’s Chalk likewise says each use increases the HP restored per charge.
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The sources do not establish a precise HP amount or percentage increase. Treat the Vessel as a permanent efficiency upgrade, not as a consumable heal: carrying it alone does not improve your Pulse.
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- Find and interact with a Beacon.
- Open the Mether’s Pulse upgrade menu.
- Choose Improve Efficiency and spend a Synaptic Vessel.
The upgrade takes effect when applied at the Beacon; simply picking up or carrying the item does not activate it.
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Where to find early Synaptic Vessels
Buy one from Merrick in southern Marrow Keep
Merrick sells a Synaptic Vessel for 1,500 coin. Open his Rare Findings inventory to find it. This purchase is reported by Nerd’s Chalk, the Gamer Guides checklist, and PowerPyx.
Defeat Grisha in the Flooded Village
Another early Vessel is reported as a reward for defeating Grisha in the Flooded Village. The route appears in the Nerd’s Chalk guide and the Gamer Guides checklist.
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Search south of Stonebled Gate Beacon
Look around the nearby camp, beside boxes near a campfire. Both Nerd’s Chalk and PowerPyx point to this pickup.
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Should you upgrade healing efficiency or carry more charges?
These upgrades address different limits. A Synaptic Vessel makes each Mether’s Pulse charge heal more; a Revered Gland increases the number of charges you can carry.
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- Choose a Vessel if you usually reach the next Beacon with charges left but want each heal to restore more health.
- Choose a Revered Gland if you regularly run out of charges before reaching a Beacon.
This is a practical way to identify your current constraint, not a controlled comparison of builds. Applying available Vessels before a difficult boss or unfamiliar area is one guide’s recommendation, rather than a universal rule.
More locations—and why totals differ
Published guides do not agree on a definitive number of Synaptic Vessels. Gamer Guides lists 19 Vessel markers, while Gamerpillar’s video, published August 27, 2026, describes 17 locations. PowerPyx lists 23 healing upgrades in total, combining Vessels with Revered Glands, so that figure is not a Vessel-only count. These totals may reflect different scopes or guide versions; they should not be treated as equivalent or reconciled into a single confirmed total.
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For additional route leads, PowerPyx names locations at Stonebled Gate, Mushroom Village, Outskirts of Nochte, Citadel of Penance, One Legged Wolf/Temple of Vatra, Sester’s Gate, Gate of Infinity, Castigator’s Keep, Abandoned Outpost, Seeping Mire, and Sanguine Caverns. Its list also includes the Merrick purchase and the camp pickup near Stonebled Gate.
The Gamer Guides checklist offers more specific landmarks: a Vessel inside a statue reached by crossing bridges over bookshelves after a jump pad; one in front of a trial; one in a skeletal pillar northeast of Revenant Graves; one on a courtyard chalice; one in a secret room reached after drinking an elixir and interacting with an altar; and one on a post-corruption route at Seeping Mire Beacon. Because this checklist includes community-submitted directions, use those clues as map aids rather than official route instructions.
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Can you collect missed healing upgrades later?
PowerPyx says missed healing upgrades can be collected in free roam after the final boss, before entering New Game+. This is a third-party guide claim rather than an officially confirmed rule.
Across the cited sources, the exact health restored by a Vessel, the number that can be applied in one playthrough, version-specific balance values, and a reconciled total are not established. The location directions are also third-party guide material, not official developer documentation.
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