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Repair common Windows errors and clear accumulated junk for a smoother, more stable PC - no reinstall needed.Free scan · no reinstallYes. Chickens edited to resist avian influenza could still become infected: in a 2023 study, nine of 10 edited birds avoided infection after a low-dose challenge, but infections occurred when the exposure was 1,000 times higher. The work is a proof of concept for partial resistance to one flu strain under controlled conditions—not evidence of immunity to bird flu generally.
What did the researchers change?
Idoko-Akoh and colleagues used CRISPR/Cas9 to alter the chicken ANP32A gene, introducing two amino-acid substitutions, N129I and D130N. The change was intended to disrupt an interaction between the host protein and influenza’s polymerase, a viral component that depends on host ANP32 proteins to function.
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The study, published in Nature Communications on 10 October 2023, tested the low-pathogenic avian influenza strain H9N2-UDL. The directly inoculated birds were two weeks old. This was a controlled challenge experiment, not a test of exposure in farms or other field conditions. Read the study in Nature Communications.
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How well did the edit protect the chickens?
At the lower challenge dose, 103 plaque-forming units (PFU) per bird, nine of 10 edited chickens remained uninfected. The one reported infection was low and transient. Researchers did not observe onward transmission in that experiment; the Roslin Institute’s summary also reports that the virus did not spread to other chickens. See the Roslin Institute’s summary.
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That result is evidence of resistance under the study’s particular low-dose exposure—not a guarantee that an edited chicken cannot catch the virus. The experiment tested one strain and a specific inoculation dose, so it does not establish protection against every avian influenza strain or under ordinary farm exposure.
What happened with a higher dose?
When the birds received 106 PFU per bird—1,000 times the lower inoculum—breakthrough infections occurred. Viruses isolated from edited birds had polymerase mutations associated with adapting to the edited ANP32A protein.
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The findings show why a single edit may not be enough: viruses that overcome the initial barrier can adapt. In the study, breakthrough virus could also use ANP32B and ANP32E, other members of the host protein family. The authors’ abstract describes the work as “a first proof of concept step” and says multiple genetic modifications will be needed to curtail viral escape.
Why not edit the other ANP32 genes too?
In chicken-cell experiments, removing ANP32A alone did not eliminate viral growth. Removing ANP32A, ANP32B and ANP32E together did eliminate viral growth in the reported experiments. That is a cell-culture result, not proof that chickens with all three genes edited would be healthy, resistant in the field or suitable for farming. The authors cautioned that extensive editing could harm animal health or fitness.
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Did the edited birds appear healthy and lay eggs normally?
The researchers’ preliminary assessment found no observed differences in growth, external appearance, behaviour or vaccination response on the measures reported. Four edited hens were included in the egg-production observation. They began laying at 20 weeks and produced an average comparable to wild-type hens—5.75 eggs per hen per week, measured over two months.
Those observations are limited by the small number of hens and short measurement period. They do not establish long-term health, lifetime egg production or commercial-scale productivity.
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Does this mean gene-edited chickens are ready for farms?
No. The study was conducted in regulated research settings, with birds bred and maintained under UK Home Office licensing. The published evidence describes laboratory research; it does not establish commercial availability, regulatory approval or field deployment of these chickens. Nor does it show that the edits protect people from influenza.
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