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oxDNA vs simDRIFT

Both stand on physics simulation software. Which one you can start free with, which one lets you read the code, and what each costs once you pay.

oxDNA

Free plan LinuxMacSelf-hosted

oxDNA combines coarse-grained DNA and RNA simulation with scriptable control and trajectory analysis. It is suited to technical users who can compile the GPL-licensed software and accept its single-device simulation limit.

Visit oxDNA

simDRIFT

Free plan LinuxWindows

simDRIFT provides configurable GPU simulations for diffusion-weighted MRI modeling and teaching. Its hardware requirements and stated modeling limits should be checked before configuring larger experiments.

Visit simDRIFT

The facts

oxDNAsimDRIFT
Free planYesYes
Open sourceNot publishedNot published
Runs onLinux, Mac, Self-hostedLinux, Windows
Lowest paid planFree or on requestNot published
Plans published1None
MakerNot publishedsimDRIFT
Websitelorenzo-rovigatti.github.iosimdrift.readthedocs.io
On physics simulation software#53 of 89#57 of 89

oxDNA: what it does well

  • Supports four documented nucleic-acid force fields
  • Provides molecular dynamics and Monte Carlo methods
  • Includes Python simulation bindings
  • Offers trajectory analysis utilities
  • Free GPL-3.0 open source

What to know first

  • Simulations run on single CPU cores or GPUs
  • Monte Carlo simulations run serially
  • Compilation requires CMake and C++14 g++
  • Python tools specify Python 3.11 or newer

simDRIFT: what it does well

  • Mesh-free Monte Carlo tissue simulations
  • Configurable fibers and isotropic cell models
  • Built-in DBSI, ABCD, and NODDI schemes
  • Exports trajectories, NIfTI signals, and logs
  • Linux and Windows desktop support

What to know first

  • Requires a CUDA device with compute capability 3+
  • Cell random-walk model assumes zero exchange
  • Higher cell fractions can increase runtime substantially
  • Documentation recommends no more than four fiber bundles

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