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Candida auris (also called Candidozyma auris) is a yeast that can live on a person without causing symptoms or cause a serious infection. It is difficult to manage because it spreads readily in healthcare settings, can persist on people and surfaces, is often resistant to antifungal drugs, and can be misidentified without specialized laboratory methods. A positive screening result alone does not mean someone has an infection that needs treatment.
What is Candida auris?
Candida auris, abbreviated C. auris, is a type of yeast. It can colonize a person—meaning it is present on or in the body without causing illness—or cause a clinical infection. The distinction matters: the organism’s presence is not, by itself, proof of disease.
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C. auris has drawn attention because it can spread between patients in healthcare facilities, survive on surfaces and shared equipment, and resist commonly used antifungal medicines. Some strains are resistant to all three major classes of antifungal drugs.
Does a positive C. auris test mean someone is infected?
No. A positive screening test or detection at a site such as the respiratory tract or in urine may reflect colonization rather than an infection. CDC says not to treat a patient who has no signs or symptoms of infection, including someone who is colonized. Treatment decisions depend on clinical assessment, not a screening result alone.
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| Situation | What it means | Usual response |
|---|---|---|
| Colonization or detection without symptoms | C. auris is present, but there is no evidence of clinical infection. | CDC does not recommend antifungal treatment solely for this finding. Infection-control precautions still apply. |
| Clinical infection | The patient has signs or symptoms of illness attributed to C. auris. | A clinician determines treatment based on the patient’s condition, infection site, age, and susceptibility results. |
Why does C. auris spread in healthcare facilities?
People can carry C. auris for long periods, potentially indefinitely, and contaminate nearby surfaces or equipment. Examples include bedrails, doorknobs, and blood-pressure cuffs. The yeast can persist in the healthcare environment, creating opportunities for transmission if hands, rooms, or reusable equipment are not appropriately cleaned and disinfected.
Healthcare facilities use infection-control measures for both colonized and infected patients. CDC guidance includes hand hygiene, appropriate precautions, thorough daily and terminal room cleaning, and cleaning and disinfection of reusable equipment after use. Facilities should use products with EPA-registered claims for C. auris and communicate a patient’s status when transferring or referring them. These are healthcare infection-control recommendations, not a recommendation to use a particular household cleaner.
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Why can C. auris be hard to identify?
Accurate identification may require specialized laboratory methods, including sequencing or mass spectrometry. CDC describes MALDI-TOF mass spectrometry as the most reliable identification method. If a laboratory misidentifies the yeast, clinicians may not recognize the organism promptly or choose the right follow-up testing.
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One free scan finds every outdated or missing driver and matches the right update for your exact hardware.Free scan · exact hardware matchSusceptibility interpretation also has a limitation: the Clinical and Laboratory Standards Institute has not established C. auris-specific breakpoints. CDC provides tentative breakpoints for interim use, so results need to be interpreted by qualified clinicians and laboratories rather than treated as a simple, universally settled threshold.
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Why is treatment difficult?
Resistance can limit drug choices
Many C. auris samples resist antifungal medicines. In its U.S. summary dated December 15, 2025, CDC reported that over 90% of U.S. C. auris samples were resistant to fluconazole. The same summary reported that echinocandin-resistant infections were less than 1%, while noting that such infections were increasing. These figures describe the United States, not a global resistance rate.
Echinocandins remain CDC’s recommended initial treatment for most clinical infections in patients older than two months, but resistance to this class and reports of strains resistant to all three major antifungal classes make some infections much harder to treat. The evidence for managing echinocandin-resistant and pan-resistant cases remains limited.
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A positive test is not the same as disease
Because colonization does not necessarily cause illness, clinicians must distinguish a person carrying the yeast from someone with a clinical infection. Treating a test result without signs or symptoms is not CDC’s recommendation; the clinical team evaluates the patient and determines whether infection is present.
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When infection is suspected or confirmed, treatment choices can depend on susceptibility testing, the infection site and severity, the patient’s age and condition, and how the patient responds. Resistance or a lack of improvement may require reassessment. CDC advises close monitoring and consideration of infectious-disease consultation; it does not establish one treatment that works for every resistant infection.
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How does CDC guidance vary by age and resistance?
CDC’s clinical treatment guidance, dated April 24, 2024, is for healthcare providers. It gives different initial approaches for infants younger than two months and for older patients, and identifies situations in which clinicians may consider another option.
| Clinical situation | CDC guidance |
|---|---|
| Clinical infection in adults and children older than two months | An echinocandin is recommended as initial therapy for most patients. |
| Clinical infection in infants younger than two months | Amphotericin B deoxycholate is recommended initially. If the infant does not respond, liposomal amphotericin B may be considered. |
| Echinocandin resistance or no improvement after five days | Consider liposomal amphotericin B, with the decision guided by the patient’s circumstances and clinical team. |
| Pan-resistant infection | Investigational drugs may be considered in particular cases; treatment evidence is limited. |
These are clinician-directed recommendations, not instructions for self-treatment. Drug choice and monitoring belong to the treating team, which can account for susceptibility results and patient-specific factors.
Why infection control continues after treatment
Antifungal treatment addresses clinical infection; it does not remove the need for precautions against transmission. A patient may remain colonized for a long time, and the organism can persist in the environment. For that reason, healthcare facilities continue appropriate precautions, environmental cleaning, and equipment disinfection for colonized as well as infected patients.
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