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Random freezes, missing sound and display glitches usually trace back to one bad driver. Find and replace yours safely.Free scan · under a minuteA 2018 analytical method showed how one liquid sample could be calibrated for as many as 71 inorganic elements in a single ICP-MS measurement. The approach was demonstrated on 15 liquids, from waters and beverages to biological samples, with reported analysis times ranging from seconds to several minutes.
That result describes a specific calibration and instrument arrangement—not a promise that every liquid, laboratory or modern ICP-MS system routinely screens 71 elements at once. The study’s importance is that it addressed the time and sample use of conventional sequential measurements by distributing ions of different masses across a flat plane for simultaneous detection.
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What the 71-element claim actually means
“71 elements” is the maximum reported for the method described by M. Bäuchle and colleagues in RSC Advances 8 (2018), page 37008 (DOI 10.1039/c8ra07070a). Chemistry World summarized the work on 21 December 2018. The number refers to inorganic elements that the calibration approach could quantify from one liquid sample in the demonstrated ICP-MS setup.
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The reported element span ran from lithium to uranium. Those endpoints indicate a broad mass range rather than a list of 71 elements that should be expected in ordinary drinking water, blood or another particular liquid. The report does not establish equal sensitivity, accuracy or speed for every element across every matrix.
How the ICP-MS measurement works
From liquid to ions
Inductively coupled plasma mass spectrometry (ICP-MS) introduces a prepared liquid into a very hot plasma. The plasma converts material in the sample into charged particles, or ions. A mass spectrometer then separates those ions according to their mass-to-charge characteristics, and the measured signals are converted into element amounts through calibration.
Calibration is the central point of the 2018 result. Instead of treating each element as an entirely separate run, the method establishes how signals from many elements relate to known concentrations in standards. Once that relationship is established, one sample introduction can provide the signals needed for a multi-element result.
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The instrument arrangement described in the report focuses ions and distributes ions of different masses along a flat plane. In effect, ions that would otherwise be read one after another are directed to different positions for detection. The geometry is what enables simultaneous collection of many mass signals rather than a sequence of mass settings.
The report presents this as a way to quantify as many as 71 inorganic elements from one sample at once. It does not provide, in the accessible summary, a complete detector map, a full list of calibration standards or a quantitative uncertainty budget, so those details should not be inferred from the headline.
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Why simultaneous measurement can matter
Traditional ICP-MS workflows commonly identify selected elements sequentially: the instrument measures one mass or a group of masses, changes its measurement conditions, and continues until the requested list is complete. Checking more elements therefore extends instrument time and consumes more of the sample as additional measurements are made.
The simultaneous approach changes that trade-off. A single introduction can support a broad elemental profile, which is useful when the analyst does not know in advance which elements will matter or when the sample volume is limited. The benefit is most apparent in screening and exploratory work, where a wide list is more valuable than repeatedly returning to the same vial.
The report gives a qualitative comparison, not a controlled performance table against a conventional instrument. It does not establish that simultaneous detection is always faster, more sensitive or less expensive. Matrix effects, preparation, calibration quality and the need to confirm individual results still govern whether the output is fit for a particular decision.
Sequential and simultaneous ICP-MS in context
| Comparison point | Sequential ICP-MS as described in the report | 71-element calibration approach |
|---|---|---|
| Elements measured per sample | Elements are identified one after another. | Up to 71 inorganic elements can be quantified from one sample at once. |
| Instrument time | More requested elements require additional sequential measurements. | The report gives analysis times from seconds to several minutes for the tested samples. |
| Sample use | Additional element checks consume more sample. | One sample introduction supplies the simultaneous multi-element measurement described. |
| Evidence base | Presented as the conventional comparison in the 2018 report. | Demonstrated on 15 liquid samples in the reported study. |
| Performance detail available in the report | Qualitative description only. | No quantitative head-to-head accuracy or detection-limit table is provided in the accessible summary. |
This table should be read as a description of the reported workflow distinction, not as a universal specification for all sequential or simultaneous ICP-MS instruments.
What liquids were tested
The team led by Timothy Bromage of New York University College of Dentistry tested 15 samples. Chemistry World identifies several categories: different waters from around the world, beer, wine, milk, saliva and blood. This mix matters because liquids differ substantially in dissolved salts, organic material and other constituents that can influence ion formation and measurement.
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Demonstrating the calibration across water, beverages and biological fluids is broader than testing a single laboratory standard. It still remains a finite demonstration. The report does not say that every water type, alcoholic drink, dairy product or clinical specimen will produce the same speed or quality of result.
For an analyst, the sensible interpretation is matrix-specific validation. A method that works on a water sample may require different preparation, dilution or calibration checks for milk or blood. The 15-sample demonstration shows reach across several classes of liquid; it does not remove the need to verify recovery, interferences and precision for a new sample type.
How long did the analysis take?
The reported analysis time ranged from seconds to several minutes. Chemistry World presents that range as a result of the demonstration, not as a guaranteed turnaround time for every sample. A clean, relatively simple liquid and a complex biological matrix should not be assumed to behave identically.
“Analysis time” also needs careful interpretation. The summary does not specify a universal clock that includes every stage of collection, digestion, dilution, filtration, calibration and quality control. The seconds-to-minutes figure describes the reported measurement performance, while a real laboratory workflow may include substantial preparation before the instrument reads the sample.
Compared with a sequential list of many elements, simultaneous acquisition can reduce the time spent repeating instrument measurements. Whether that reduction survives in routine work depends on how many elements are required, how often calibration must be checked and whether any results need a separate confirmatory run.
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What the method does—and does not—establish
Established by the 2018 demonstration
- A calibration approach for ICP-MS was reported for measuring up to 71 inorganic elements in one liquid sample.
- The setup focused and distributed ions of different masses along a flat plane to support simultaneous detection.
- Fifteen samples were tested, including waters, beer, wine, milk, saliva and blood.
- The reported elemental range extended from lithium to uranium.
- The report gave measurement times from seconds to several minutes.
- The comparison with conventional ICP-MS concerned sequential measurement, instrument time and sample consumption.
Questions the report leaves open
- It does not provide a complete quantitative accuracy, precision or detection-limit comparison with sequential ICP-MS.
- It does not establish that all 71 elements are equally measurable in every matrix.
- It does not show that the method is routinely available on current commercial instruments.
- It does not, by itself, prove adoption by clinical, environmental, food or industrial laboratories.
- It does not establish whether later methods have validated, modified or superseded the approach.
How a laboratory would interpret a result
Start with the analytical question
A broad elemental screen is useful only when the laboratory defines what decisions the result will support. Environmental monitoring may prioritize trace contaminants; food work may focus on nutritional or toxic elements; biological samples may require a different list and stricter controls. The 71-element ceiling should not substitute for a justified target list.
Match calibration to the matrix
Calibration standards must represent the concentration range and measurement conditions expected for the samples. Matrix differences between a standard solution and a real sample can change signal behavior. The report establishes the multi-element concept, but it does not supply a universal calibration recipe for all waters, beverages or body fluids.
Check unexpected values
A simultaneous result is a screening advantage, not immunity from interference. An unusual concentration, a value near a reporting limit or a result that conflicts with sample history deserves review under the laboratory’s quality system. Confirmation may require a repeat preparation, dilution, an alternate measurement condition or another validated method; which option is appropriate depends on the element and matrix.
Report the scope honestly
A defensible report should identify the elements included, the sample type, the calibration range and the date and version of the method used. It should not describe the result as a universal 71-element capability unless the specific instrument and laboratory have demonstrated that scope.
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The wording “checks for 71 elements” sounds like a routine consumer test or a fixed feature shared by all ICP-MS systems. The underlying result is narrower: a published calibration and instrument configuration demonstrated simultaneous multi-element analysis on 15 liquids. The number is a reported maximum, not a population statistic and not a guarantee about an unknown sample.
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Likewise, “simultaneously” describes how ions were measured in the arrangement. It does not mean every stage of laboratory work happens at the same instant. Sampling, preparation, calibration, quality-control checks and interpretation remain separate tasks.
The method is also not equivalent to proving that all 71 elements are present. It provides a way to measure signals associated with a broad set of inorganic elements; the concentration of any particular element may be below detection, absent, affected by the matrix or outside the validated range.
Publication date and present-day status
The underlying paper was published in 2018, and the accessible account is dated 21 December 2018. That date is important because instrument designs, software and laboratory practices can change. The cited account does not establish subsequent independent validation, routine adoption or a later method that replaced it.
Accordingly, the safest current description is historical and technical: the paper reported a simultaneous ICP-MS calibration capable of handling up to 71 inorganic elements in the tested liquid samples. Anyone considering the approach for present-day work should look for a current instrument specification, a validated application note or newer primary studies for the exact matrix and elements required.
Bottom line for readers
One liquid sample can be evaluated for many elements at once when the ICP-MS system is calibrated and arranged to separate ions of different masses across a flat detection plane. The 2018 Bäuchle et al. study reported up to 71 inorganic elements, lithium through uranium, across 15 samples and measurement times of seconds to several minutes. The result demonstrates a promising way to reduce sequential measurements, instrument time and sample use, but it is not evidence that every liquid or every ICP-MS laboratory routinely delivers a 71-element result.
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