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Mild diarrhea or stomach upset can happen while taking antibiotics. Keep up your fluids, and contact your prescriber or pharmacist before using an antidiarrheal or changing your medicine. Get medical advice promptly if diarrhea lasts more than two days, or you develop fever, significant abdominal pain, dehydration, or black or bloody stool.
What antibiotic-related diarrhea can look like
Antibiotic-associated diarrhea is commonly described as three or more loose, watery stools a day after antibiotic use. Mild symptoms may start within hours or days of beginning treatment and often settle within a few days after starting or finishing it. Mayo Clinic estimates that about 1 in 5 people who take antibiotics gets antibiotic-associated diarrhea; that estimate does not mean the risk is the same for every antibiotic or population. Mayo Clinic’s overview provides symptom and cause information.
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What to do for mild symptoms
Replace lost fluids
Drink regularly. Water, broth, and fluids containing electrolytes can help replace what diarrhea takes from your body. An oral rehydration solution, available without a prescription, combines water, electrolytes, and sugar to support fluid replacement; it does not treat the underlying cause of diarrhea. Mayo Clinic’s treatment guidance discusses hydration options.
Check before taking an antidiarrheal
Do not assume an over-the-counter antidiarrheal is appropriate. Ask a healthcare professional first: some medicines may be unsuitable if a bacterial infection such as C. difficile is involved. A clinician can advise based on your symptoms and medical situation. Mayo Clinic recommends professional advice before using these medicines.
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Do not stop or switch the antibiotic on your own
Contact the prescriber about symptoms rather than independently stopping or changing the prescribed course. Whether to adjust treatment depends on the circumstances. The American Gastroenterological Association’s patient resource advises contacting your healthcare provider before stopping antibiotics.
When to get medical advice
Contact a healthcare professional if diarrhea continues for more than two days, or if you have abdominal pain, fever, signs of dehydration, or black, tarry, or bloody stool. Seek prompt assessment for severe symptoms. One possible cause of serious antibiotic-associated diarrhea is Clostridioides difficile (C. difficile), which requires medical attention. Mayo Clinic lists warning signs and causes.
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- Support Your Gut: Our probiotic contains 10 diverse high-quality probiotic strains and organic prebiotics - synergistically working together to support your gut health. Expertly crafted to support occasional constipation, diarrhea, gas & bloating!
- Survives the Gut: From start to finish - this probiotic is designed to survive the gut & maximize the colonization of our strains. We use a shelf-stable bottle, acid-resistant capsules, and 60 Billion Colony forming units (CFU) to achieve this!
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Do probiotics help?
The evidence does not establish that probiotics reliably relieve symptoms or that all products work alike. A Cochrane review, with searches current through March 3, 2025, found probiotics may reduce antibiotic-associated diarrhea and C. difficile-associated diarrhea. It describes a possible small, short-term preventive benefit for antibiotic users who do not have weakened immune systems, while noting that more large studies are needed in low-risk groups. Read Cochrane’s review summary.
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Lowering the chance of problems in the future
- Use antibiotics only when they are needed and prescribed for your situation.
- Wash your hands regularly.
- Tell your clinician if you have had antibiotic-associated diarrhea or C. difficile before; that history can inform care. Mayo Clinic’s prevention guidance covers these steps.
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