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AMD announced the EPYC 4005 Series on May 13, 2025. Codenamed “Grado,” the six-processor family brings Zen 5 cores, ECC memory support, PCIe 5.0 and one-socket server operation to an AM5-based platform. The range runs from six to 16 cores, while the EPYC 4585PX adds 128 MB of L3 cache through 3D V-Cache.

EPYC 4005 is not simply a Ryzen processor that works in every AM5 motherboard. The CPU, motherboard firmware, memory configuration, remote-management features and chassis all need to be validated for a dependable server.

What AMD announced

EPYC 4005 is AMD’s entry-level Zen 5 server family for small businesses, hosted services, edge deployments, storage systems, towers, blades and compact workstations. Every model is designed for a single-socket system, with between six and 16 cores and 12 to 32 threads.

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The platform uses the AM5 package family associated with Ryzen 7000 and Ryzen 9000, but AMD positions it for server-oriented systems with ECC support, security features and vendor-validated platforms. AMD lists two DDR5 memory channels, up to 192 GB of DDR5 ECC memory, DDR5-5600 support under specified one-DIMM-per-channel conditions, and 28 PCIe 5.0 lanes. See AMD’s launch announcement and datasheet for platform details.

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for AMD EPYC 9754 128 Core Bergamo 2.25GHz (100-000001234) EPYC 9004 Series Socket SP5 ZEN4 256MB L3 Bulk/Tray Pack (Unlocked) Server Processor
  • For AMD EPYC 9754 128 Core Bergamo 2.25GHz (100-000001234) EPYC 9004 Series Socket SP5 ZEN4 256MB L3 Bulk / Tray Pack (Unlocked) Server Processor

The family also includes AMD security technologies such as the AMD Secure Processor, Infinity Guard, hardware-accelerated encryption, memory encryption, TPM 2.0 support and TSME. Actual security, management and error-reporting functionality depends on the motherboard and system vendor.

EPYC 4005 specifications and launch pricing

The prices below are AMD’s announced one-thousand-unit (1KU) prices in U.S. dollars from May 2025. They are not guaranteed retail prices in September 2026.

Processor Cores / threads Base / boost L3 cache Default TDP AMD 1KU price
EPYC 4245P 6 / 12 3.9 / 5.4 GHz 32 MB 65 W $239
EPYC 4345P 8 / 16 3.8 / up to 5.5 GHz* 32 MB 65 W $329
EPYC 4465P 12 / 24 3.4 / 5.4 GHz 64 MB 65 W $399
EPYC 4545P 16 / 32 3.0 / 5.4 GHz 64 MB 65 W $549
EPYC 4565P 16 / 32 4.3 / 5.7 GHz 64 MB 170 W $589
EPYC 4585PX 16 / 32 4.3 / 5.7 GHz 128 MB 170 W $699

*AMD’s launch announcement and product materials list the EPYC 4345P at up to 5.5 GHz, while one datasheet result lists 5.3 GHz. Buyers should check the latest AMD documentation for the final specification. AMD’s materials also use “EPYC 4245” in one datasheet table, while launch and product listings identify it as the EPYC 4245P.

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Why the EPYC 4585PX has 3D V-Cache

The EPYC 4585PX is the only EPYC 4005 model with 3D V-Cache. It has 16 cores, a 4.3 GHz base clock, up to 5.7 GHz boost, a 170 W default TDP and 128 MB of total L3 cache.

The cache is not distributed identically across all cores. Technical reporting describes one CCD with 96 MB of L3 cache—64 MB of stacked 3D V-Cache plus 32 MB of conventional cache—and a second CCD with 32 MB. The total figure therefore does not mean every core has the same local cache arrangement.

Extra cache can help applications that repeatedly access a working set of data, including some game servers, databases, simulations, software-development workloads and specialized virtualized services. It is not a universal performance guarantee. Streaming workloads, I/O-bound services and jobs limited primarily by memory bandwidth or instruction throughput may see little benefit over the EPYC 4565P.

Rank #2
Hewlett Packard Enterprise ProLiant DL365 Gen11 Rack Server w/one AMD EPYC 9115 Processor, 2.6GHz 16c 2P 8x32GB-R 8SFF MR408i-o 2x480GB SSD 2x800W PS (HPE Smart Choice P83035-005)
  • Dual Processor Support: Supports and includes 2 AMD EPYC processors installed for enhanced computing performance
  • Processor Configuration: Features 2 installed AMD EPYC processors for powerful server operations
  • AMD Processor Technology: Equipped with AMD processor manufacturer components for reliable performance
  • EPYC Processor Type: Utilizes AMD EPYC processor type designed for enterprise-level server applications
  • 5th Generation Processing: Powered by 5th Gen AMD EPYC 9115 processors running at 2.60 GHz with hexadeca-core architecture

AM5 compatibility does not mean universal motherboard compatibility

EPYC 4005 uses the AM5 platform, but a Ryzen-compatible motherboard is not automatically an EPYC-compatible motherboard. A board must explicitly list the processor and provide the required BIOS or AGESA support.

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Before buying a board, check all of the following:

  • The exact EPYC 4005 model appears on the vendor’s supported-CPU list.
  • The required BIOS version is available and can be installed.
  • ECC memory is supported and properly reported by firmware.
  • The board supports the desired DIMM type, capacity and arrangement.
  • PCIe slots, M.2 connectors and storage ports provide the required lanes.
  • A BMC, IPMI or equivalent remote-management feature is available if the server requires it.
  • The board and chassis have appropriate firmware, cooling and support documentation.

Server-oriented AM5 products from vendors such as Supermicro, ASRock Rack, ASUS and Gigabyte may provide better validation and management than a typical consumer board. The exact features vary by model.

ECC memory, capacity and platform limits

AMD lists support for up to 192 GB of DDR5 ECC memory through a two-channel memory interface. DDR5-5600 is specified under conditions including one DIMM per channel, but the motherboard’s qualified-memory list and firmware determine what works in a particular system.

ECC can detect and correct certain memory errors, improving reliability, but it does not prevent every form of data corruption or hardware failure. The CPU’s ECC capability is only part of the system. DIMMs, motherboard traces, firmware, error logging and operating-system support all matter.

EPYC 4005 is also a relatively compact server platform rather than a replacement for larger EPYC systems. Its two memory channels, 192 GB listed maximum, 28 PCIe 5.0 lanes and one-socket limit make it attractive for small deployments, but restrictive for memory-heavy virtualization, large databases, many NVMe drives or multiple accelerators.

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EPYC 4005 versus EPYC 4004

EPYC 4005 is the Zen 5 successor to the Zen 4 EPYC 4004 family. Both target entry-level, single-socket AM5-oriented server systems, but the newer range adds Zen 5 cores, DDR5-5600 support, new 12- and 16-core 65 W options, and the 4585PX cache-enhanced model.

Rank #3
HPE ProLiant DL385 Gen10 Plus Server with one AMD EPYC 7313 Processor, 32 GB Memory, P408i-a Storage Controller, Eight Small Form Factor Drive Bays and a 800W Power Supply
  • High Performance Server: Features an AMD EPYC 7313 processor with a speed of 1.44 GHz and 32 GB of DDR4 memory for fast performance.
  • Expandable Storage: Includes an P408i-a storage controller and 8 SFF drive bays for flexible storage options.
  • Modern Design: Has a sleek, modern style with a black finish and ergonomic keyboard for comfortable use.
  • Easy Setup: Comes with an 800W power supply and pre-installed operating system for quick installation.
  • Reliable Connectivity: Offers multiple USB and Ethernet ports for seamless connectivity to other devices.

EPYC 4004 may still make sense where a previous-generation processor or board is substantially discounted. However, buyers should not assume that an EPYC 4004 motherboard will support EPYC 4005 without a firmware update. Compatibility remains a board-vendor decision. AMD’s EPYC 4004 announcement provides the prior-generation reference point.

EPYC 4005 versus Ryzen 9000

Both families use Zen 5 and belong to the AM5 ecosystem, but they serve different buyers.

EPYC 4005 Ryzen 9000
Server-oriented validation and system availability Much broader consumer motherboard availability
ECC support positioned for server deployments ECC behavior varies widely by motherboard
Enterprise security and management features More enthusiast and desktop-oriented features
Up to 16 cores, including a 65 W 16-core model Often lower street prices and easier retail sourcing
Designed for validated server configurations Better fit for desktops and ordinary workstations

A Ryzen 9000 system can be the better choice for a workstation or homelab where ECC and remote management are not essential. EPYC 4005 is more appropriate when validated ECC operation, server firmware, enterprise operating-system support or a server vendor’s platform matters more than the widest motherboard selection.

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EPYC 4005 versus Intel entry-level Xeon

AMD positions EPYC 4005 against processors such as Intel Xeon E-2400 and Xeon 6300-class systems. AMD-linked partner material reports that the EPYC 4565P delivered up to 1.83 times the performance of Intel’s top Xeon 6300P model in a Phoronix Test Suite comparison.

That is an AMD-provided or AMD-linked suite-level result, not a universal application benchmark. Results depend on the selected workloads, software versions, compiler settings, memory, power limits and system configuration. Intel may still be preferable where an OEM platform, management stack, existing infrastructure or workload-specific optimization is more important than AMD’s launch performance positioning.

Which EPYC 4005 processor should you choose?

EPYC 4245P

Choose the six-core 4245P for light virtualization, file serving, monitoring, small-business applications and low-power servers where the CPU budget is the main constraint.

Rank #4
HPE ProLiant DL145 Gen11 2U Rack Server - 1 x AMD EPYC 8024P 2.40 GHz - 16 GB RAM - 480 GB SSD - Serial ATA/600 Controller - AMD Chip
  • Number of Processors Supported: 1
  • Number of Processors Installed: 1
  • Processor Manufacturer: AMD
  • Processor Type: EPYC
  • Processor Generation: 4th Gen

EPYC 4345P

The eight-core 4345P is a balanced 65 W option for moderate virtualization, containers, general-purpose services and software development.

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EPYC 4465P

The 12-core 4465P suits concurrent services, containers and virtualization when additional cores and 64 MB of cache are useful but a 170 W thermal budget is undesirable.

EPYC 4545P

The 4545P is the efficiency-focused 16-core model. It is a strong fit for dense systems, sustained parallel workloads and deployments where keeping power and cooling requirements near 65 W matters.

EPYC 4565P

Choose the 4565P when high clock speeds and conventional all-core performance are more important than low power. Its 170 W TDP requires serious cooling and adequate chassis airflow.

EPYC 4585PX

The 4585PX is worth considering when the workload is demonstrably cache-sensitive and the premium over the 4565P is justified. It may benefit selected game servers, databases, simulations and development workloads, but benchmarking the actual application is preferable to assuming that 128 MB of cache will always be faster.

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When EPYC 4005 is the wrong platform

Choose a larger EPYC platform if the system needs more than 192 GB of memory, substantially more PCIe connectivity, registered or load-reduced memory, multiple sockets, or a large enterprise expansion topology. EPYC 9005 is a more natural fit for high-end virtualization, databases and I/O-heavy deployments.

Best Value
AMD EPYC 4005 4465P Dodeca-core (12 Core) 3.40 GHz Processor - Box
  • The processor features Socket AM5 socket for installation on the PCB
  • EPYC product line processor for better usability and increased efficiency
  • Dodeca-core (12 Core) processor core allows multitasking with great reliability and fast processing speed
  • 64 MB of L3 cache memory provides excellent hit rate in short access time enabling improved system performance
  • Processor with 3.40 GHz clock speed for reliable and fast execution of instructions to ensure maximum convenience and feasibility

Choose Ryzen 9000 if consumer motherboard choice, retail availability and desktop features matter more than server validation. Choose a complete OEM or partner-built system if the organization cannot afford to troubleshoot BIOS, ECC, cooling and chassis compatibility itself.

AMD’s EPYC 8005 is another option for more specialized server, telco and RAN workloads, although it is not aimed at buyers specifically seeking inexpensive AM5 hardware. See the EPYC 8005 launch coverage for that platform’s positioning.

Cooling, expansion and deployment warnings

The 4565P and 4585PX are 170 W processors. A compact chassis or low-airflow workstation cooler may not be sufficient under sustained load. Cooling depends on ambient temperature, fan policy, chassis design, workload and BIOS power settings.

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The 28 PCIe 5.0 lanes can be enough for a compact storage or networking server, but lane sharing and bifurcation can limit real-world expansion. Check the motherboard diagram before planning multiple NVMe drives, high-speed networking cards or accelerators.

AMD also supports RAIDXpert2 for Server on EPYC 4005 and EPYC 4004 platforms, according to technical reporting, but exact operating-system, driver and device support is software-version dependent. Confirm current documentation before designing a production storage array.

Standard EPYC 4005 versus Embedded EPYC 4005

AMD has separate standard server and embedded product pages using similar EPYC 4005 branding. The Embedded EPYC 4005 line should not automatically be treated as identical to the standard EPYC 4005 server lineup. Embedded products can involve different lifecycle commitments, firmware, validation and vendor availability.

Verdict

EPYC 4005 is a compelling compact server platform for buyers who need Zen 5 performance, ECC memory and server-oriented validation without moving to a larger EPYC socket. The 4545P is the efficiency-focused 16-core choice, the 4565P favors high clock speed, and the 4585PX is the specialist option for cache-sensitive workloads.

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Its AM5 design keeps systems comparatively compact, but it does not remove the need for server-grade planning. Confirm motherboard and BIOS support, validate ECC operation, budget for cooling on 170 W models, and account for the platform’s two memory channels, 192 GB memory ceiling, 28 PCIe lanes and single-socket limit before purchasing.

Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on Amazon at the time of purchase will apply.